Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria

Self-assembly of phenylalanine is linked to amyloid formation toxicity in phenylketonuria disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying experimental conditions and transforms to a gel state at saturated concentration. Biophysical methods including nu...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Virender, Rai, Ratan Kumar, Arora, Ashish, Sinha, Neeraj, Thakur, Ashwani Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902384/
https://www.ncbi.nlm.nih.gov/pubmed/24464217
http://dx.doi.org/10.1038/srep03875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902384/
https://www.ncbi.nlm.nih.gov/pubmed/24464217
http://dx.doi.org/10.1038/srep03875

Ejemplares similares