Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association

Nucleophosmin (NPM1/B23) is a nucleolar protein implicated in growth-associated functions, in which the RNA binding activity of B23 plays essential roles in ribosome biogenesis. The C-terminal globular domain (CTD) of B23 has been believed to be the RNA binding domain because the splicing variant B2...

Descripción completa

Detalles Bibliográficos
Autores principales: Hisaoka, Miharu, Nagata, Kyosuke, Okuwaki, Mitsuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902904/
https://www.ncbi.nlm.nih.gov/pubmed/24106084
http://dx.doi.org/10.1093/nar/gkt897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902904/
https://www.ncbi.nlm.nih.gov/pubmed/24106084
http://dx.doi.org/10.1093/nar/gkt897

Ejemplares similares