Cargando…

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster

RNA editing by deamination of specific adenosine bases to inosines during pre-mRNA processing generates edited isoforms of proteins. Recoding RNA editing is more widespread in Drosophila than in vertebrates. Editing levels rise strongly at metamorphosis, and Adar(5G1) null mutant flies lack editing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xianghua, Overton, Ian M., Baines, Richard A., Keegan, Liam P., O’Connell, Mary A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902911/ https://www.ncbi.nlm.nih.gov/pubmed/24137011 http://dx.doi.org/10.1093/nar/gkt909

Ejemplares similares

Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
por: Phelps, Kelly J., et al.
Publicado: (2015)

RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells
por: Wang, Yuru, et al.
Publicado: (2019)

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method
por: Wang, Yuru, et al.
Publicado: (2016)

Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions
por: Mamolen, Megan, et al.
Publicado: (2010)

A protein–protein interaction underlies the molecular basis for substrate recognition by an adenosine-to-inosine RNA-editing enzyme
por: Rajendren, Suba, et al.
Publicado: (2018)

Regulation of RNA editing by intracellular acidification
por: Malik, Turnee N, et al.
Publicado: (2021)

Oxidation alters the architecture of the phenylalanyl-tRNA synthetase editing domain to confer hyperaccuracy
por: Srinivas, Pooja, et al.
Publicado: (2021)

Coordination between aminoacylation and editing to protect against proteotoxicity
por: Zhang, Hong, et al.
Publicado: (2023)

Enhanced Cas12a editing in mammalian cells and zebrafish
por: Liu, Pengpeng, et al.
Publicado: (2019)

Impact of alanyl-tRNA synthetase editing deficiency in yeast
por: Zhang, Hong, et al.
Publicado: (2021)

Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria
por: Hilander, Taru, et al.
Publicado: (2018)

DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA
por: Zheng, Yuxuan, et al.
Publicado: (2017)

In-depth assessment of the PAM compatibility and editing activities of Cas9 variants
por: Zhang, Weiwei, et al.
Publicado: (2021)

Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases
por: Zivkovic, Igor, et al.
Publicado: (2022)

Nucleobase modification by an RNA enzyme
por: Poudyal, Raghav R., et al.
Publicado: (2017)

Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases
por: Mizrahi, Rena A., et al.
Publicado: (2012)

RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting
por: Rajappa-Titu, Lional, et al.
Publicado: (2016)

Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae
por: Mohler, Kyle, et al.
Publicado: (2017)

Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation
por: Zheng, Wen-Qiang, et al.
Publicado: (2020)

Discovery of potent and versatile CRISPR–Cas9 inhibitors engineered for chemically controllable genome editing
por: Song, Guoxu, et al.
Publicado: (2022)

C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme–DNA complex and confer high enzyme processivity
por: Strzałka, Agnieszka, et al.
Publicado: (2017)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase
por: Chen, Xin, et al.
Publicado: (2011)

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
por: Mussolino, Claudio, et al.
Publicado: (2011)

Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing
por: Hu, Qing-Hua, et al.
Publicado: (2013)

Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
por: Wang, Yupeng, et al.
Publicado: (2014)

A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities
por: Chen, Yun, et al.
Publicado: (2018)

Stereospecificity control in aminoacyl-tRNA-synthetases: new evidence of d-amino acids activation and editing
por: Rybak, Mariia Yu, et al.
Publicado: (2019)

Bi-PE: bi-directional priming improves CRISPR/Cas9 prime editing in mammalian cells
por: Tao, Rui, et al.
Publicado: (2022)

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
por: Keegan, Liam P, et al.
Publicado: (2004)

Atomic force microscopy of the EcoKI Type I DNA restriction enzyme bound to DNA shows enzyme dimerization and DNA looping
por: Neaves, Kelly J., et al.
Publicado: (2009)

Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages
por: Olorunniji, Femi J., et al.
Publicado: (2015)

Type I restriction endonucleases are true catalytic enzymes
por: Bianco, Piero R., et al.
Publicado: (2009)

Complementation of aprataxin deficiency by base excision repair enzymes
por: Çağlayan, Melike, et al.
Publicado: (2015)

Target site cleavage by the monomeric restriction enzyme BcnI requires translocation to a random DNA sequence and a switch in enzyme orientation
por: Sasnauskas, Giedrius, et al.
Publicado: (2011)

Single-site DNA cleavage by Type III restriction endonuclease requires a site-bound enzyme and a trans-acting enzyme that are ATPase-activated
por: Ahmad, Ishtiyaq, et al.
Publicado: (2018)

A ‘new lease of life’: FnCpf1 possesses DNA cleavage activity for genome editing in human cells
por: Tu, Mengjun, et al.
Publicado: (2017)

Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain
por: Ji, Quan-Quan, et al.
Publicado: (2017)

DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase
por: Weinert, Brian T., et al.
Publicado: (2007)

Tetrameric restriction enzymes: expansion to the GIY-YIG nuclease family
por: Gasiunas, Giedrius, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ouie1u4i28mhetlp3243fj41t2