Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability

The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition, repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile protein degraded by the cytoplasmic ubiquitin-ligases β-TrCP1/FBXW1 and Ppa/FBXL14. Using a short hairpin RNA scre...

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Detalles Bibliográficos
Autores principales: Viñas-Castells, Rosa, Frías, Álex, Robles-Lanuza, Estefanía, Zhang, Kun, Longmore, Gregory D., García de Herreros, Antonio, Díaz, Víctor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902928/
https://www.ncbi.nlm.nih.gov/pubmed/24157836
http://dx.doi.org/10.1093/nar/gkt935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902928/
https://www.ncbi.nlm.nih.gov/pubmed/24157836
http://dx.doi.org/10.1093/nar/gkt935

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