Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest

The tumor suppressor protein p53 exhibits high affinity to the response elements regulating cell cycle arrest genes (CCA-sites), but relatively low affinity to the sites associated with apoptosis (Apo-sites). This in vivo tendency cannot be explained solely by the p53-DNA binding constants measured...

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Detalles Bibliográficos
Autores principales: Cui, Feng, Zhurkin, Victor B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902933/
https://www.ncbi.nlm.nih.gov/pubmed/24153113
http://dx.doi.org/10.1093/nar/gkt943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902933/
https://www.ncbi.nlm.nih.gov/pubmed/24153113
http://dx.doi.org/10.1093/nar/gkt943

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