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Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest
The tumor suppressor protein p53 exhibits high affinity to the response elements regulating cell cycle arrest genes (CCA-sites), but relatively low affinity to the sites associated with apoptosis (Apo-sites). This in vivo tendency cannot be explained solely by the p53-DNA binding constants measured...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902933/ https://www.ncbi.nlm.nih.gov/pubmed/24153113 http://dx.doi.org/10.1093/nar/gkt943 |