The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage

Tight control of antigen-receptor gene rearrangement is required to preserve genome integrity and prevent the occurrence of leukemia and lymphoma. Nonetheless, mistakes can happen, leading to the generation of aberrant rearrangements, such as Tcra/d-Igh inter-locus translocations that are a hallmark...

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Detalles Bibliográficos
Autores principales: Chaumeil, Julie, Micsinai, Mariann, Ntziachristos, Panagiotis, Roth, David B., Aifantis, Iannis, Kluger, Yuval, Deriano, Ludovic, Skok, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903180/
https://www.ncbi.nlm.nih.gov/pubmed/23900513
http://dx.doi.org/10.1038/ncomms3231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903180/
https://www.ncbi.nlm.nih.gov/pubmed/23900513
http://dx.doi.org/10.1038/ncomms3231

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