Hypoxia Inducible Factor-2α Regulates the Development of Retinal Astrocytic Network by Maintaining Adequate Supply of Astrocyte Progenitors

Here we investigate the role of hypoxia inducible factor (HIF)-2α in coordinating the development of retinal astrocytic and vascular networks. Three Cre mouse lines were used to disrupt floxed Hif-2α, including Rosa26(CreERT2), Tie2(Cre), and GFAP(Cre). Global Hif-2α disruption by Rosa26(CreERT2) le...

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Detalles Bibliográficos
Autores principales: Duan, Li-Juan, Takeda, Kotaro, Fong, Guo-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903483/
https://www.ncbi.nlm.nih.gov/pubmed/24475033
http://dx.doi.org/10.1371/journal.pone.0084736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903483/
https://www.ncbi.nlm.nih.gov/pubmed/24475033
http://dx.doi.org/10.1371/journal.pone.0084736

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