Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex

The optimization of antibodies is a desirable goal towards the development of better therapeutic strategies. The antibody 11K2 was previously developed as a therapeutic tool for inflammatory diseases, and displays very high affinity (4.6 pM) for its antigen the chemokine MCP-1 (monocyte chemo-attrac...

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Detalles Bibliográficos
Autores principales: Kiyoshi, Masato, Caaveiro, Jose M. M., Miura, Eri, Nagatoishi, Satoru, Nakakido, Makoto, Soga, Shinji, Shirai, Hiroki, Kawabata, Shigeki, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903617/
https://www.ncbi.nlm.nih.gov/pubmed/24475232
http://dx.doi.org/10.1371/journal.pone.0087099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903617/
https://www.ncbi.nlm.nih.gov/pubmed/24475232
http://dx.doi.org/10.1371/journal.pone.0087099

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