Tissue-Specific Expression of Transgenic Secreted ACE in Vasculature Can Restore Normal Kidney Functions, but Not Blood Pressure, of Ace-/- Mice

Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All of these defects are cured by transgenic expr...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Saurabh, Kessler, Sean P., Colucci, Juliana Almada, Yamashita, Michifumi, Senanayake, Preenie deS, Sen, Ganes C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903672/
https://www.ncbi.nlm.nih.gov/pubmed/24475296
http://dx.doi.org/10.1371/journal.pone.0087484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903672/
https://www.ncbi.nlm.nih.gov/pubmed/24475296
http://dx.doi.org/10.1371/journal.pone.0087484

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