Ubiquilin-1 Overexpression Increases the Lifespan and Delays Accumulation of Huntingtin Aggregates in the R6/2 Mouse Model of Huntington's Disease

Huntington's Disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of a polyglutamine tract in huntingtin (htt) protein. The expansion leads to increased htt aggregation and toxicity. Factors that aid in the clearance of mutant huntingtin proteins should relieve the...

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Detalles Bibliográficos
Autores principales: Safren, Nathaniel, El Ayadi, Amina, Chang, Lydia, Terrillion, Chantelle E., Gould, Todd D., Boehning, Darren F., Monteiro, Mervyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903676/
https://www.ncbi.nlm.nih.gov/pubmed/24475300
http://dx.doi.org/10.1371/journal.pone.0087513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903676/
https://www.ncbi.nlm.nih.gov/pubmed/24475300
http://dx.doi.org/10.1371/journal.pone.0087513

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