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Ubiquilin-1 Overexpression Increases the Lifespan and Delays Accumulation of Huntingtin Aggregates in the R6/2 Mouse Model of Huntington's Disease

Huntington's Disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of a polyglutamine tract in huntingtin (htt) protein. The expansion leads to increased htt aggregation and toxicity. Factors that aid in the clearance of mutant huntingtin proteins should relieve the...

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Detalles Bibliográficos
Autores principales:	Safren, Nathaniel, El Ayadi, Amina, Chang, Lydia, Terrillion, Chantelle E., Gould, Todd D., Boehning, Darren F., Monteiro, Mervyn J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903676/ https://www.ncbi.nlm.nih.gov/pubmed/24475300 http://dx.doi.org/10.1371/journal.pone.0087513

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