Inhibition of HDAC1 and DNMT1 Modulate RGS10 Expression and Decrease Ovarian Cancer Chemoresistance

RGS10 is an important regulator of cell survival and chemoresistance in ovarian cancer. We recently showed that RGS10 transcript expression is suppressed during acquired chemoresistance in ovarian cancer. The suppression of RGS10 is due to DNA hypermethylation and histone deacetylation, two importan...

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Detalles Bibliográficos
Autores principales: Cacan, Ercan, Ali, Mourad W., Boyd, Nathaniel H., Hooks, Shelley B., Greer, Susanna F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903677/
https://www.ncbi.nlm.nih.gov/pubmed/24475290
http://dx.doi.org/10.1371/journal.pone.0087455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903677/
https://www.ncbi.nlm.nih.gov/pubmed/24475290
http://dx.doi.org/10.1371/journal.pone.0087455

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