Inclusion of CD80 in HSV Targets the Recombinant Virus to PD-L1 on DCs and Allows Productive Infection and Robust Immune Responses

CD80 plays a critical role in stimulation of T cells and subsequent control of infection. To investigate the effect of CD80 on HSV-1 infection, we constructed a recombinant HSV-1 virus that expresses two copies of the CD80 gene in place of the latency associated transcript (LAT). This mutant virus (...

Descripción completa

Detalles Bibliográficos
Autores principales: Mott, Kevin R., Allen, Sariah J., Zandian, Mandana, Akbari, Omid, Hamrah, Pedram, Maazi, Hadi, Wechsler, Steven L., Sharpe, Arlene H., Freeman, Gordon J., Ghiasi, Homayon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903765/
https://www.ncbi.nlm.nih.gov/pubmed/24475315
http://dx.doi.org/10.1371/journal.pone.0087617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903765/
https://www.ncbi.nlm.nih.gov/pubmed/24475315
http://dx.doi.org/10.1371/journal.pone.0087617

Ejemplares similares