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Inclusion of CD80 in HSV Targets the Recombinant Virus to PD-L1 on DCs and Allows Productive Infection and Robust Immune Responses

CD80 plays a critical role in stimulation of T cells and subsequent control of infection. To investigate the effect of CD80 on HSV-1 infection, we constructed a recombinant HSV-1 virus that expresses two copies of the CD80 gene in place of the latency associated transcript (LAT). This mutant virus (...

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Detalles Bibliográficos
Autores principales:	Mott, Kevin R., Allen, Sariah J., Zandian, Mandana, Akbari, Omid, Hamrah, Pedram, Maazi, Hadi, Wechsler, Steven L., Sharpe, Arlene H., Freeman, Gordon J., Ghiasi, Homayon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903765/ https://www.ncbi.nlm.nih.gov/pubmed/24475315 http://dx.doi.org/10.1371/journal.pone.0087617

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