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RML prions act through Mahogunin and Attractin-independent pathways

While the conversion of the normal form of prion protein to a conformationally distinct pathogenic form is recognized to be the primary cause of prion disease, it is not clear how this leads to spongiform change, neuronal dysfunction and death. Mahogunin ring finger-1 (Mgrn1) and Attractin (Atrn) nu...

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Detalles Bibliográficos
Autores principales: Gunn, Teresa M, Carlson, George A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904309/
https://www.ncbi.nlm.nih.gov/pubmed/23787699
http://dx.doi.org/10.4161/pri.25054