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Prion protein and susceptibility to kainate-induced seizures: Genetic pitfalls in the use of PrP knockout mice

Prion protein (PrP) is a cell surface glycoprotein which is required for susceptibility to prion infection and disease. However, PrP is expressed in many different cell types located in numerous organs. Therefore, in addition to its role in prion diseases, PrP may have a large variety of other biolo...

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Detalles Bibliográficos
Autores principales: Striebel, James F, Race, Brent, Chesebro, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904312/
https://www.ncbi.nlm.nih.gov/pubmed/23851597
http://dx.doi.org/10.4161/pri.25738