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The story of stolen chaperones: How overexpression of Q/N proteins cures yeast prions

Prions are self-seeding alternate protein conformations. Most yeast prions contain glutamine/asparagine (Q/N)-rich domains that promote the formation of amyloid-like prion aggregates. Chaperones, including Hsp104 and Sis1, are required to continually break these aggregates into smaller “seeds.” Decr...

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Detalles Bibliográficos
Autores principales: Derkatch, Irina L, Liebman, Susan W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904315/
https://www.ncbi.nlm.nih.gov/pubmed/23924684
http://dx.doi.org/10.4161/pri.26021