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mCSM: predicting the effects of mutations in proteins using graph-based signatures
Motivation: Mutations play fundamental roles in evolution by introducing diversity into genomes. Missense mutations in structural genes may become either selectively advantageous or disadvantageous to the organism by affecting protein stability and/or interfering with interactions between partners....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904523/ https://www.ncbi.nlm.nih.gov/pubmed/24281696 http://dx.doi.org/10.1093/bioinformatics/btt691 |