EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells

BACKGROUND: Epstein-Barr Virus (EBV) latently infects ~10% of gastric carcinomas (GC). Epstein-Barr Nuclear Antigen 1 (EBNA1) is expressed in EBV-associated GC, and can bind host DNA, where it may impact cellular gene regulation. Here, we show that EBNA1 binds directly to DNA upstream of the diverge...

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Detalles Bibliográficos
Autores principales: Lu, Fang, Tempera, Italo, Lee, Hyunna T, DeWispelaere, Karen, Lieberman, Paul M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904692/
https://www.ncbi.nlm.nih.gov/pubmed/24460791
http://dx.doi.org/10.1186/1743-422X-11-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904692/
https://www.ncbi.nlm.nih.gov/pubmed/24460791
http://dx.doi.org/10.1186/1743-422X-11-12

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