High-resolution Xist binding maps reveal 2-step spreading during X-inactivation

The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes(1-3). During XCI, Xist coats the future inactive X (Xi)(4) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation cen...

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Detalles Bibliográficos
Autores principales: Simon, Matthew D., Pinter, Stefan F., Fang, Rui, Sarma, Kavitha, Rutenberg-Schoenberg, Michael, Bowman, Sarah K., Kesner, Barry A., Maier, Verena K., Kingston, Robert E., Lee, Jeannie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904790/
https://www.ncbi.nlm.nih.gov/pubmed/24162848
http://dx.doi.org/10.1038/nature12719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904790/
https://www.ncbi.nlm.nih.gov/pubmed/24162848
http://dx.doi.org/10.1038/nature12719

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