Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor

Accumulating evidence indicates that a small population of cancer stem cells (CSCs) is involved in intrinsic resistance to cancer treatment. The hypoxic microenvironment is an important stem cell niche that promotes the persistence of CSCs in tumors. Our aim here was to elucidate the role of hypoxia...

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Detalles Bibliográficos
Autores principales: Murakami, Akiko, Takahashi, Fumiyuki, Nurwidya, Fariz, Kobayashi, Isao, Minakata, Kunihiko, Hashimoto, Muneaki, Nara, Takeshi, Kato, Motoyasu, Tajima, Ken, Shimada, Naoko, Iwakami, Shin-ichiro, Moriyama, Mariko, Moriyama, Hiroyuki, Koizumi, Fumiaki, Takahashi, Kazuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904884/
https://www.ncbi.nlm.nih.gov/pubmed/24489728
http://dx.doi.org/10.1371/journal.pone.0086459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904884/
https://www.ncbi.nlm.nih.gov/pubmed/24489728
http://dx.doi.org/10.1371/journal.pone.0086459

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