Sequential Treatment with Cytarabine and Decitabine Has an Increased Anti-Leukemia Effect Compared to Cytarabine Alone in Xenograft Models of Childhood Acute Myeloid Leukemia

The current interest in epigenetic priming is underpinned by the belief that remodelling of the epigenetic landscape will sensitise tumours to subsequent therapy. In this pre-clinical study, paediatric AML cells expanded in culture and primary AML xenografts were treated with decitabine, a DNA demet...

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Detalles Bibliográficos
Autores principales: Leonard, Sarah M., Perry, Tracey, Woodman, Ciarán B., Kearns, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905025/
https://www.ncbi.nlm.nih.gov/pubmed/24489920
http://dx.doi.org/10.1371/journal.pone.0087475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905025/
https://www.ncbi.nlm.nih.gov/pubmed/24489920
http://dx.doi.org/10.1371/journal.pone.0087475

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