Cargando…

New Mechanisms to Explain the Effects of Added Lactose Fines on the Dispersion Performance of Adhesive Mixtures for Inhalation

Fine excipient particles or ‘fines’ have been shown to improve the dispersion performance of carrier-based formulations for dry powder inhalation. Mechanistic formulation studies have focussed mainly on explaining this positive effect. Previous studies have shown that higher drug contents may cause...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grasmeijer, Floris, Lexmond, Anne J., van den Noort, Maarten, Hagedoorn, Paul, Hickey, Anthony J., Frijlink, Henderik W., de Boer, Anne H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905031/ https://www.ncbi.nlm.nih.gov/pubmed/24489969 http://dx.doi.org/10.1371/journal.pone.0087825

Ejemplares similares

Drug Content Effects on the Dispersion Performance of Adhesive Mixtures for Inhalation
por: Grasmeijer, Floris, et al.
Publicado: (2013)

Mixing Time Effects on the Dispersion Performance of Adhesive Mixtures for Inhalation
por: Grasmeijer, Floris, et al.
Publicado: (2013)

Correction: Mixing Time Effects on the Dispersion Performance of Adhesive Mixtures for Inhalation
por: Grasmeijer, Floris, et al.
Publicado: (2013)

Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation
por: Sibum, Imco, et al.
Publicado: (2019)

Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops(®) High Dose Dry Powder Inhalation Device While Maintaining Dispersibility
por: Sibum, Imco, et al.
Publicado: (2020)

Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine
por: Sibum, Imco, et al.
Publicado: (2019)

Prerequisites for a dry powder inhaler for children with cystic fibrosis
por: Lexmond, Anne J., et al.
Publicado: (2017)

Effect of Inhaler Design Variables on Paediatric Use of Dry Powder Inhalers
por: Lexmond, Anne J., et al.
Publicado: (2014)

Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson’s disease
por: Luinstra, Marianne, et al.
Publicado: (2019)

Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma
por: Gafar, Fajri, et al.
Publicado: (2018)

Can Patients with Parkinson’s Disease Use Dry Powder Inhalers during Off Periods?
por: Luinstra, M., et al.
Publicado: (2015)

Targeting the small airways with dry powder adenosine: a challenging concept
por: van der Wiel, Erica, et al.
Publicado: (2017)

The Effects of Relative Humidity on the Flowability and Dispersion Performance of Lactose Mixtures
por: Lu, Xiang-Yun, et al.
Publicado: (2017)

In Vitro Performance Testing of the Novel Medspray® Wet Aerosol Inhaler Based on the Principle of Rayleigh Break-up
por: de Boer, Anne H., et al.
Publicado: (2007)

Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients
por: Hoppentocht, Marcel, et al.
Publicado: (2016)

A User-Friendly Model for Spray Drying to Aid Pharmaceutical Product Development
por: Grasmeijer, Niels, et al.
Publicado: (2013)

Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers
por: de Reus, Y. A., et al.
Publicado: (2022)

Inhalation of vaccines and antiviral drugs to fight respiratory virus infections: reasons to prioritize the pulmonary route of administration
por: Heida, Rick, et al.
Publicado: (2023)

Colistin dry powder inhalation with the Twincer™: An effective and more patient friendly alternative to nebulization
por: Akkerman-Nijland, A. M., et al.
Publicado: (2020)

Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma
por: Cox, Claire A., et al.
Publicado: (2019)

Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination
por: Tomar, Jasmine, et al.
Publicado: (2019)

Effect of compression pressure on inhalation grade lactose as carrier for dry powder inhalations
por: Raut, Neha Sureshrao, et al.
Publicado: (2016)

CLSM as Quantitative Method to Determine the Size of Drug Crystals in a Solid Dispersion
por: de Waard, Hans, et al.
Publicado: (2011)

Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scientific Rationale
por: Janssen, Rob, et al.
Publicado: (2019)

Cross border, highly individualised treatment of a patient with challenging extensively drug-resistant tuberculosis
por: Akkerman, Onno W., et al.
Publicado: (2018)

Effect of Lactose Pseudopolymorphic Transition on the Aerosolization Performance of Drug/Carrier Mixtures
por: Della Bella, Andrea, et al.
Publicado: (2019)

Physicochemical analysis and nonisothermal kinetic study of sertraline–lactose binary mixtures
por: Ghaderi, Faranak, et al.
Publicado: (2016)

Eradication of Pseudomonas aeruginosa in cystic fibrosis patients with inhalation of dry powder tobramycin
por: Akkerman-Nijland, Anne M., et al.
Publicado: (2020)

Lactose Sensitivity and Lactose Malabsorption: The 2 Faces of Lactose Intolerance
por: Bouchoucha, Michel, et al.
Publicado: (2021)

Performance Testing of a Homemade Aerosol Generator for Pulmonary Administration of Dry Powder Formulations to Mice
por: Heida, Rick, et al.
Publicado: (2023)

The Perception of Lactose-Related Symptoms of Patients with Lactose Malabsorption
por: Di Stefano, Michele, et al.
Publicado: (2022)

Critical physicochemical attributes of chitosan nanoparticles admixed lactose-PEG 3000 microparticles in pulmonary inhalation
por: Alhajj, Nasser, et al.
Publicado: (2020)

Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling
por: Kou, Xiang, et al.
Publicado: (2017)

Bistable Behavior of the Lac Operon in E. Coli When Induced with a Mixture of Lactose and TMG
por: Díaz-Hernández, Orlando, et al.
Publicado: (2010)

Acute and Chronic Effects of Dietary Lactose in Adult Rats Are not Explained by Residual Intestinal Lactase Activity
por: van de Heijning, Bert J. M., et al.
Publicado: (2015)

Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern
por: Pazesh, Samaneh, et al.
Publicado: (2019)

Lactose intolerance
por: Wiley, Andrea S
Publicado: (2020)

Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems
por: Broesder, Annemarie, et al.
Publicado: (2021)

Lactose Malabsorption and Lactose Intolerance in Children with Inflammatory Bowel Diseases
por: Jasielska, Martyna, et al.
Publicado: (2019)

“Lactose free” depression- Antidepressant with and without lactose registered in Croatia
por: Svetinović, D., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n0s913nepciu4m3bjr30uv3hsc