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Exploring the potential benefits of stratified false discovery rates for region-based testing of association with rare genetic variation

When analyzing the data that arises from exome or whole-genome sequencing studies, window-based tests, (i.e., tests that jointly analyze all genetic data in a small genomic region), are very popular. However, power is known to be quite low for finding associations with phenotypes using these tests,...

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Detalles Bibliográficos
Autores principales: Xu, ChangJiang, Ciampi, Antonio, Greenwood, Celia M. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905218/
https://www.ncbi.nlm.nih.gov/pubmed/24523729
http://dx.doi.org/10.3389/fgene.2014.00011