Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult stem cell biology. Through ubiquitination and degradation of Wnt receptors, the transmembrane E3 ubiquitin ligase ZNRF3 and related RNF43 antagonize Wnt signalling. Rspo...

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Detalles Bibliográficos
Autores principales: Zebisch, Matthias, Xu, Yang, Krastev, Christos, MacDonald, Bryan T., Chen, Maorong, Gilbert, Robert J. C., He, Xi, Jones, E. Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905715/
https://www.ncbi.nlm.nih.gov/pubmed/24225776
http://dx.doi.org/10.1038/ncomms3787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905715/
https://www.ncbi.nlm.nih.gov/pubmed/24225776
http://dx.doi.org/10.1038/ncomms3787

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