Structural basis of AMPK regulation by small molecule activators

AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Binding of AMP causes allosteric activation of the enzyme and binding of either AMP or ADP promotes and maintains the phosphor...

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Detalles Bibliográficos
Autores principales: Xiao, Bing, Sanders, Matthew J., Carmena, David, Bright, Nicola J., Haire, Lesley F., Underwood, Elizabeth, Patel, Bhakti R., Heath, Richard B., Walker, Philip A., Hallen, Stefan, Giordanetto, Fabrizio, Martin, Stephen R., Carling, David, Gamblin, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905731/
https://www.ncbi.nlm.nih.gov/pubmed/24352254
http://dx.doi.org/10.1038/ncomms4017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905731/
https://www.ncbi.nlm.nih.gov/pubmed/24352254
http://dx.doi.org/10.1038/ncomms4017

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