A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice

Huntington’s disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger, modulating neuronal metabolism. Using an electrophysiological approach in R6/2 HD slices, we obser...

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Detalles Bibliográficos
Autores principales: Acuña, Aníbal I., Esparza, Magdalena, Kramm, Carlos, Beltrán, Felipe A., Parra, Alejandra V., Cepeda, Carlos, Toro, Carlos A., Vidal, René L., Hetz, Claudio, Concha, Ilona I., Brauchi, Sebastián, Levine, Michael S., Castro, Maite A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905737/
https://www.ncbi.nlm.nih.gov/pubmed/24336051
http://dx.doi.org/10.1038/ncomms3917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905737/
https://www.ncbi.nlm.nih.gov/pubmed/24336051
http://dx.doi.org/10.1038/ncomms3917

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