E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin

Weak protein interactions between ubiquitin and the ubiquitin-proteasome system (UPS) enzymes that mediate its covalent attachment to substrates serve to position ubiquitin for optimal catalytic transfer. We show that a small molecule inhibitor of the E2 ubiquitin conjugating enzyme Cdc34A, called C...

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Detalles Bibliográficos
Autores principales: Huang, Hao, Ceccarelli, Derek F, Orlicky, Stephen, St-Cyr, Daniel J., Ziemba, Amy, Garg, Pankaj, Plamondon, Serge, Auer, Manfred, Sidhu, Sachdev, Marinier, Anne, Kleiger, Gary, Tyers, Mike, Sicheri, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905752/
https://www.ncbi.nlm.nih.gov/pubmed/24316736
http://dx.doi.org/10.1038/nchembio.1412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905752/
https://www.ncbi.nlm.nih.gov/pubmed/24316736
http://dx.doi.org/10.1038/nchembio.1412

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