In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. Previous studies, which characterized miRNA function, revealed their involvement in fundamental biological processes. Importantly, miRNA expression is deregulated in many human diseases. Specific inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Mayumi, Yamada, Naoki, Hatakeyama, Hiroto, Murata, Manami, Sato, Yusuke, Minakawa, Noriaki, Harashima, Hideyoshi, Matsuda, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905841/
https://www.ncbi.nlm.nih.gov/pubmed/24030710
http://dx.doi.org/10.1093/nar/gkt823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905841/
https://www.ncbi.nlm.nih.gov/pubmed/24030710
http://dx.doi.org/10.1093/nar/gkt823

Ejemplares similares