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In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. Previous studies, which characterized miRNA function, revealed their involvement in fundamental biological processes. Importantly, miRNA expression is deregulated in many human diseases. Specific inhibi...

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Detalles Bibliográficos
Autores principales:	Takahashi, Mayumi, Yamada, Naoki, Hatakeyama, Hiroto, Murata, Manami, Sato, Yusuke, Minakawa, Noriaki, Harashima, Hideyoshi, Matsuda, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905841/ https://www.ncbi.nlm.nih.gov/pubmed/24030710 http://dx.doi.org/10.1093/nar/gkt823

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