Solution structure of the major G-quadruplex formed in the human VEGF promoter in K(+): insights into loop interactions of the parallel G-quadruplexes

Vascular endothelial growth factor (VEGF) proximal promoter region contains a poly G/C-rich element that is essential for basal and inducible VEGF expression. The guanine-rich strand on this tract has been shown to form the DNA G-quadruplex structure, whose stabilization by small molecules can suppr...

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Detalles Bibliográficos
Autores principales: Agrawal, Prashansa, Hatzakis, Emmanuel, Guo, Kexiao, Carver, Megan, Yang, Danzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905851/
https://www.ncbi.nlm.nih.gov/pubmed/24005038
http://dx.doi.org/10.1093/nar/gkt784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905851/
https://www.ncbi.nlm.nih.gov/pubmed/24005038
http://dx.doi.org/10.1093/nar/gkt784

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