Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study

Topoisomerase IB (Top1) inhibitors, such as camptothecin (CPT), stabilize the Top1-DNA cleavage complex in a DNA sequence-dependent manner. The sequence selectivity of Top1 inhibitors is important for targeting specific genomic sequences of therapeutic value. However, the molecular mechanisms underl...

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Detalles Bibliográficos
Autores principales: Siu, Fung-Ming, Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905861/
https://www.ncbi.nlm.nih.gov/pubmed/24021629
http://dx.doi.org/10.1093/nar/gkt791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905861/
https://www.ncbi.nlm.nih.gov/pubmed/24021629
http://dx.doi.org/10.1093/nar/gkt791

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