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Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study
Topoisomerase IB (Top1) inhibitors, such as camptothecin (CPT), stabilize the Top1-DNA cleavage complex in a DNA sequence-dependent manner. The sequence selectivity of Top1 inhibitors is important for targeting specific genomic sequences of therapeutic value. However, the molecular mechanisms underl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905861/ https://www.ncbi.nlm.nih.gov/pubmed/24021629 http://dx.doi.org/10.1093/nar/gkt791 |