On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

Type II topoisomerases (Top2s) alter DNA topology via the formation of an enzyme–DNA adduct termed cleavage complex, which harbors a transient double-strand break in one DNA to allow the passage of another. Agents targeting human Top2s are clinically active anticancer drugs whose trapping of Top2-me...

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Detalles Bibliográficos
Autores principales: Wu, Chyuan-Chuan, Li, Yi-Ching, Wang, Ying-Ren, Li, Tsai-Kun, Chan, Nei-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905874/
https://www.ncbi.nlm.nih.gov/pubmed/24038465
http://dx.doi.org/10.1093/nar/gkt828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905874/
https://www.ncbi.nlm.nih.gov/pubmed/24038465
http://dx.doi.org/10.1093/nar/gkt828

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