Self-duplexing CUG repeats selectively inhibit mutant huntingtin expression

Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by the expansion of the CAG repeat in the translated sequence of the HTT gene. This expansion generates a mutant huntingtin protein that contains an abnormally elongated polyglutamine tract, which, together with mutant transcri...

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Detalles Bibliográficos
Autores principales: Fiszer, Agnieszka, Olejniczak, Marta, Galka-Marciniak, Paulina, Mykowska, Agnieszka, Krzyzosiak, Wlodzimierz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905887/
https://www.ncbi.nlm.nih.gov/pubmed/24038471
http://dx.doi.org/10.1093/nar/gkt825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905887/
https://www.ncbi.nlm.nih.gov/pubmed/24038471
http://dx.doi.org/10.1093/nar/gkt825

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