An High-Throughput In Vivo Screening System to Select H3K4-Specific Histone Demethylase Inhibitors

BACKGROUND: Histone demethylases (HDMs) have a prominent role in epigenetic regulation and are emerging as potential therapeutic cancer targets. The search for small molecules able to inhibit HDMs in vivo is very active but at the present few compounds were found to be specific for defined classes o...

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Detalles Bibliográficos
Autores principales: Mannironi, Cecilia, Proietto, Marco, Bufalieri, Francesca, Cundari, Enrico, Alagia, Angela, Danovska, Svetlana, Rinaldi, Teresa, Famiglini, Valeria, Coluccia, Antonio, La Regina, Giuseppe, Silvestri, Romano, Negri, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906020/
https://www.ncbi.nlm.nih.gov/pubmed/24489688
http://dx.doi.org/10.1371/journal.pone.0086002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906020/
https://www.ncbi.nlm.nih.gov/pubmed/24489688
http://dx.doi.org/10.1371/journal.pone.0086002

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