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An High-Throughput In Vivo Screening System to Select H3K4-Specific Histone Demethylase Inhibitors
BACKGROUND: Histone demethylases (HDMs) have a prominent role in epigenetic regulation and are emerging as potential therapeutic cancer targets. The search for small molecules able to inhibit HDMs in vivo is very active but at the present few compounds were found to be specific for defined classes o...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906020/ https://www.ncbi.nlm.nih.gov/pubmed/24489688 http://dx.doi.org/10.1371/journal.pone.0086002 |