Comprehensive Analysis to Improve the Validation Rate for Single Nucleotide Variants Detected by Next-Generation Sequencing

Next-generation sequencing (NGS) has enabled the high-throughput discovery of germline and somatic mutations. However, NGS-based variant detection is still prone to errors, resulting in inaccurate variant calls. Here, we categorized the variants detected by NGS according to total read depth (TD) and...

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Detalles Bibliográficos
Autores principales: Park, Mi-Hyun, Rhee, Hwanseok, Park, Jung Hoon, Woo, Hae-Mi, Choi, Byung-Ok, Kim, Bo-Young, Chung, Ki Wha, Cho, Yoo-Bok, Kim, Hyung Jin, Jung, Ji-Won, Koo, Soo Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906084/
https://www.ncbi.nlm.nih.gov/pubmed/24489763
http://dx.doi.org/10.1371/journal.pone.0086664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906084/
https://www.ncbi.nlm.nih.gov/pubmed/24489763
http://dx.doi.org/10.1371/journal.pone.0086664

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