Investigating and Correcting Plasma DNA Sequencing Coverage Bias to Enhance Aneuploidy Discovery

Pregnant women carry a mixture of cell-free DNA fragments from self and fetus (non-self) in their circulation. In recent years multiple independent studies have demonstrated the ability to detect fetal trisomies such as trisomy 21, the cause of Down syndrome, by Next-Generation Sequencing of materna...

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Detalles Bibliográficos
Autores principales: Chandrananda, Dineika, Thorne, Natalie P., Ganesamoorthy, Devika, Bruno, Damien L., Benjamini, Yuval, Speed, Terence P., Slater, Howard R., Bahlo, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906086/
https://www.ncbi.nlm.nih.gov/pubmed/24489824
http://dx.doi.org/10.1371/journal.pone.0086993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906086/
https://www.ncbi.nlm.nih.gov/pubmed/24489824
http://dx.doi.org/10.1371/journal.pone.0086993

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