Allo-Reactivity of Mesenchymal Stem Cells in Rhesus Macaques Is Dose and Haplotype Dependent and Limits Durable Cell Engraftment In Vivo

The emerging paradigm that MSCs are immune privileged has fostered the use of “off-the-shelf” allogeneic MSC-based therapies in human clinical trials. However, this approach ignores studies in experimental animals wherein transplantation of MSCs across MHC boundaries elicits measurable allo-immune r...

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Detalles Bibliográficos
Autores principales: Isakova, Iryna A., Lanclos, Calvin, Bruhn, Julie, Kuroda, Marcelo J., Baker, Kate C., Krishnappa, Veena, Phinney, Donald G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906169/
https://www.ncbi.nlm.nih.gov/pubmed/24489878
http://dx.doi.org/10.1371/journal.pone.0087238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906169/
https://www.ncbi.nlm.nih.gov/pubmed/24489878
http://dx.doi.org/10.1371/journal.pone.0087238

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