Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization

Oncogene-induced senescence is a permanent cell cycle arrest characterized by extensive chromatin reorganization. Here, we investigated the specific targeting and dynamics of histone H3 variants in human primary senescent cells. We show that newly synthesized epitope-tagged H3.3 is incorporated in s...

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Detalles Bibliográficos
Autores principales: Corpet, Armelle, Olbrich, Teresa, Gwerder, Myriam, Fink, Daniel, Stucki, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906242/
https://www.ncbi.nlm.nih.gov/pubmed/24200965
http://dx.doi.org/10.4161/cc.26988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906242/
https://www.ncbi.nlm.nih.gov/pubmed/24200965
http://dx.doi.org/10.4161/cc.26988

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