Rapid optical control of nociception with an ion channel photoswitch

Local anesthetics are effective in suppressing pain sensation, but most of these compounds act non-selectively, inhibiting the activity of all neurons. Moreover, their actions abate slowly, preventing precise spatial and temporal control of nociception. We have developed a photoisomerizable molecule...

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Detalles Bibliográficos
Autores principales: Mourot, Alexandre, Fehrentz, Timm, Feuvre, Yves Le, Smith, Caleb M., Herold, Christian, Dalkara, Deniz, Nagy, Frédéric, Trauner, Dirk, Kramer, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906498/
https://www.ncbi.nlm.nih.gov/pubmed/22343342
http://dx.doi.org/10.1038/nmeth.1897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906498/
https://www.ncbi.nlm.nih.gov/pubmed/22343342
http://dx.doi.org/10.1038/nmeth.1897

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