Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

BACKGROUND: A nef gene is present in all primate lentiviral genomes and is important for high viral loads and progression to AIDS in human or experimental macaque hosts of HIV or SIV, respectively. In these hosts, infection of the thymus results in a decreased output of naive T cells that may contri...

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Detalles Bibliográficos
Autores principales: Van Nuffel, Anouk, Ariën, Kevin K, Stove, Veronique, Schindler, Michael, O’Neill, Eduardo, Schmökel, Jan, Van de Walle, Inge, Naessens, Evelien, Vanderstraeten, Hanne, Van Landeghem, Kathleen, Taghon, Tom, Pulkkinen, Kati, Saksela, Kalle, Garcia, J Victor, Fackler, Oliver T, Kirchhoff, Frank, Verhasselt, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906981/
https://www.ncbi.nlm.nih.gov/pubmed/24237970
http://dx.doi.org/10.1186/1742-4690-10-137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906981/
https://www.ncbi.nlm.nih.gov/pubmed/24237970
http://dx.doi.org/10.1186/1742-4690-10-137

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