The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold

BACKGROUND: The tumor suppressor protein p53 is activated by cellular stress. DNA double strand breaks (DSBs) induce the activation of the kinase ATM, which stabilizes p53 and activates its transcriptional activity. Single cell analysis revealed that DSBs induced by gamma irradiation trigger p53 acc...

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Detalles Bibliográficos
Autores principales: Loewer, Alexander, Karanam, Ketki, Mock, Caroline, Lahav, Galit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906995/
https://www.ncbi.nlm.nih.gov/pubmed/24252182
http://dx.doi.org/10.1186/1741-7007-11-114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906995/
https://www.ncbi.nlm.nih.gov/pubmed/24252182
http://dx.doi.org/10.1186/1741-7007-11-114

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