Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation

BACKGROUND: Congenital disorders of glycosylation (CDGs) are inherited diseases caused by glycosylation defects. Incorrectly glycosylated proteins induce protein misfolding and endoplasmic reticulum (ER) stress. The most common form of CDG, PMM2-CDG, is caused by deficiency in the cytosolic enzyme p...

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Chi tiết về thư mục
Những tác giả chính: Sun, Liangwu, Zhao, Yingjun, Zhou, Kun, Freeze, Hudson H, Zhang, Yun-wu, Xu, Huaxi
Định dạng: Online Bài viết Texto
Ngôn ngữ:English
Được phát hành: BioMed Central 2013
Những chủ đề:
Research
Truy cập trực tuyến:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907076/
https://www.ncbi.nlm.nih.gov/pubmed/24305089
http://dx.doi.org/10.1186/1756-6606-6-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907076/
https://www.ncbi.nlm.nih.gov/pubmed/24305089
http://dx.doi.org/10.1186/1756-6606-6-52

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