De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function

The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences. This variation makes it difficult to evaluate PTBP1 binding to particular sites based on sequence al...

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Detalles Bibliográficos
Autores principales: Han, Areum, Stoilov, Peter, Linares, Anthony J., Zhou, Yu, Fu, Xiang-Dong, Black, Douglas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907290/
https://www.ncbi.nlm.nih.gov/pubmed/24499931
http://dx.doi.org/10.1371/journal.pcbi.1003442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907290/
https://www.ncbi.nlm.nih.gov/pubmed/24499931
http://dx.doi.org/10.1371/journal.pcbi.1003442

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