Contribution of Baicalin on the Plasma Protein Binding Displacement and CYP3A Activity Inhibition to the Pharmacokinetic Changes of Nifedipine in Rats In Vivo and In Vitro

Baicalin purified from the root of Radix scutellariae is widely used in clinical practices. This study aimed to evaluate the effect of baicalin on the pharmacokinetics of nifedipine, a CYP3A probe substrate, in rats in vivo and in vitro. In a randomised, three-period crossover study, significant cha...

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Detalles Bibliográficos
Autores principales: Cheng, Zhen-Yu, Tian, Xin, Gao, Jie, Li, Hong-Meng, Jia, Lin-Jing, Qiao, Hai-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907542/
https://www.ncbi.nlm.nih.gov/pubmed/24498050
http://dx.doi.org/10.1371/journal.pone.0087234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907542/
https://www.ncbi.nlm.nih.gov/pubmed/24498050
http://dx.doi.org/10.1371/journal.pone.0087234

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