Pharmacological AMP Kinase Activators Target the Nucleolar Organization and Control Cell Proliferation

AIMS: Phenformin, resveratrol and AICAR stimulate the energy sensor 5′-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli. Nucleolar activities are relevant to human health, because ribosome production is crucial to the development of dia...

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Detalles Bibliográficos
Autores principales: Kodiha, Mohamed, Salimi, Ali, Wang, Yi Meng, Stochaj, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907577/
https://www.ncbi.nlm.nih.gov/pubmed/24498249
http://dx.doi.org/10.1371/journal.pone.0088087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907577/
https://www.ncbi.nlm.nih.gov/pubmed/24498249
http://dx.doi.org/10.1371/journal.pone.0088087

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