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Pharmacological AMP Kinase Activators Target the Nucleolar Organization and Control Cell Proliferation
AIMS: Phenformin, resveratrol and AICAR stimulate the energy sensor 5′-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli. Nucleolar activities are relevant to human health, because ribosome production is crucial to the development of dia...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907577/ https://www.ncbi.nlm.nih.gov/pubmed/24498249 http://dx.doi.org/10.1371/journal.pone.0088087 |